Influenza, a One Health paradigm--novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential.
Identifieur interne : 000169 ( Main/Exploration ); précédent : 000168; suivant : 000170Influenza, a One Health paradigm--novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential.
Auteurs : Stephan Ludwig [Allemagne] ; Roland Zell [Allemagne] ; Martin Schwemmle [Allemagne] ; Susanne Herold [Allemagne]Source :
- International journal of medical microbiology : IJMM [ 1618-0607 ] ; 2014.
Descripteurs français
- KwdFr :
- Allemagne, Animaux, Antiviraux (usage thérapeutique), Facteurs immunologiques (usage thérapeutique), Grippe humaine (immunologie), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Humains, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Interactions hôte-pathogène, Orthomyxoviridae (), Orthomyxoviridae (pathogénicité), Recherche biomédicale (organisation et administration), Zoonoses (traitement médicamenteux).
- MESH :
- immunologie : Grippe humaine, Infections à Orthomyxoviridae.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- organisation et administration : Recherche biomédicale.
- pathogénicité : Orthomyxoviridae.
- traitement médicamenteux : Grippe humaine, Zoonoses.
- usage thérapeutique : Antiviraux, Facteurs immunologiques.
- virologie : Grippe humaine, Infections à Orthomyxoviridae.
- Allemagne, Animaux, Humains, Interactions hôte-pathogène, Orthomyxoviridae.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Biomedical Research (organization & administration), Germany, Host-Pathogen Interactions, Humans, Immunologic Factors (therapeutic use), Influenza, Human (drug therapy), Influenza, Human (immunology), Influenza, Human (virology), Orthomyxoviridae (drug effects), Orthomyxoviridae (pathogenicity), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Zoonoses (drug therapy).
- MESH :
- chemical , therapeutic use : Antiviral Agents, Immunologic Factors.
- geographic : Germany.
- drug effects : Orthomyxoviridae.
- drug therapy : Influenza, Human, Zoonoses.
- immunology : Influenza, Human, Orthomyxoviridae Infections.
- organization & administration : Biomedical Research.
- pathogenicity : Orthomyxoviridae.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections.
- Animals, Host-Pathogen Interactions, Humans.
Abstract
Influenza virus is a paradigm for a pathogen that frequently crosses the species barrier from animals to humans, causing severe disease in the human population. This ranges from frequent epidemics to occasional pandemic outbreaks with millions of death. All previous pandemics in humans were caused by animal viruses or virus reassortants carrying animal virus genes, underlining that the fight against influenza requires a One Health approach integrating human and veterinary medicine. Furthermore, the fundamental question of what enables a flu pathogen to jump from animals to humans can only be tackled in a transdisciplinary approach between virologists, immunologists and cell biologists. To address this need the German FluResearchNet was established as a first nationwide influenza research network that virtually integrates all national expertise in the field of influenza to unravel viral and host determinants of pathogenicity and species transmission and to explore novel avenues of antiviral intervention. Here we focus on the various novel anti-flu approaches that were developed as part of the FluResearchNet activities.
DOI: 10.1016/j.ijmm.2014.08.016
PubMed: 25220817
Affiliations:
- Allemagne
- Bade-Wurtemberg, District de Fribourg-en-Brisgau, District de Münster, Rhénanie-du-Nord-Westphalie
- Fribourg-en-Brisgau, Münster
Links toward previous steps (curation, corpus...)
Le document en format XML
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that frequently crosses the species barrier from animals to humans, causing severe disease in the human population. This ranges from frequent epidemics to occasional pandemic outbreaks with millions of death. All previous pandemics in humans were caused by animal viruses or virus reassortants carrying animal virus genes, underlining that the fight against influenza requires a One Health approach integrating human and veterinary medicine. Furthermore, the fundamental question of what enables a flu pathogen to jump from animals to humans can only be tackled in a transdisciplinary approach between virologists, immunologists and cell biologists. To address this need the German FluResearchNet was established as a first nationwide influenza research network that virtually integrates all national expertise in the field of influenza to unravel viral and host determinants of pathogenicity and species transmission and to explore novel avenues of antiviral intervention. Here we focus on the various novel anti-flu approaches that were developed as part of the FluResearchNet activities. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25220817</PMID><DateCompleted><Year>2015</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1618-0607</ISSN><JournalIssue CitedMedium="Internet"><Volume>304</Volume><Issue>7</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of medical microbiology : IJMM</Title><ISOAbbreviation>Int. J. Med. Microbiol.</ISOAbbreviation></Journal><ArticleTitle>Influenza, a One Health paradigm--novel therapeutic strategies to fight a zoonotic pathogen with pandemic potential.</ArticleTitle><Pagination><MedlinePgn>894-901</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijmm.2014.08.016</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1438-4221(14)00115-5</ELocationID><Abstract><AbstractText>Influenza virus is a paradigm for a pathogen that frequently crosses the species barrier from animals to humans, causing severe disease in the human population. This ranges from frequent epidemics to occasional pandemic outbreaks with millions of death. All previous pandemics in humans were caused by animal viruses or virus reassortants carrying animal virus genes, underlining that the fight against influenza requires a One Health approach integrating human and veterinary medicine. Furthermore, the fundamental question of what enables a flu pathogen to jump from animals to humans can only be tackled in a transdisciplinary approach between virologists, immunologists and cell biologists. To address this need the German FluResearchNet was established as a first nationwide influenza research network that virtually integrates all national expertise in the field of influenza to unravel viral and host determinants of pathogenicity and species transmission and to explore novel avenues of antiviral intervention. Here we focus on the various novel anti-flu approaches that were developed as part of the FluResearchNet activities. </AbstractText><CopyrightInformation>Copyright © 2014 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ludwig</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Molecular Virology (IMV), Centre for Molecular Biology of Inflammation (ZMBE), University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany. Electronic address: ludwigs@uni-muenster.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zell</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knoell Str. 2, D-07745 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwemmle</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Virology, University Medical Center Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herold</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Universities Giessen & Marburg Lung Center (UGMLC), Department of Internal Medicine II, Section of Infectious Diseases, Klinikstr. 33, D-35392 Giessen, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>08</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Int J Med Microbiol</MedlineTA><NlmUniqueID>100898849</NlmUniqueID><ISSNLinking>1438-4221</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007155">Immunologic Factors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D035843" MajorTopicYN="N">Biomedical Research</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="Y">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007155" MajorTopicYN="N">Immunologic Factors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug 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MajorTopicYN="N">Antiviral therapy</Keyword><Keyword MajorTopicYN="N">Immune modulation</Keyword><Keyword MajorTopicYN="N">Influenza virus</Keyword><Keyword MajorTopicYN="N">One Health</Keyword><Keyword MajorTopicYN="N">Polymerase complex</Keyword><Keyword MajorTopicYN="N">Signal transduction</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25220817</ArticleId><ArticleId IdType="pii">S1438-4221(14)00115-5</ArticleId><ArticleId IdType="doi">10.1016/j.ijmm.2014.08.016</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Fribourg-en-Brisgau</li><li>Münster</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Ludwig, Stephan" sort="Ludwig, Stephan" uniqKey="Ludwig S" first="Stephan" last="Ludwig">Stephan Ludwig</name></region><name sortKey="Herold, Susanne" sort="Herold, Susanne" uniqKey="Herold S" first="Susanne" last="Herold">Susanne Herold</name><name sortKey="Schwemmle, Martin" sort="Schwemmle, Martin" uniqKey="Schwemmle M" first="Martin" last="Schwemmle">Martin Schwemmle</name><name sortKey="Zell, Roland" sort="Zell, Roland" uniqKey="Zell R" first="Roland" last="Zell">Roland Zell</name></country></tree></affiliations></record>Pour 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